Velakast is a fixed-dose combination tablet developed by Aprazer Healthcare Pvt Ltd, containing Sofosbuvir 400 mg and Velpatasvir 100 mg. This combination is widely used in the treatment of chronic Hepatitis C Virus (HCV) infection in adults. Sofosbuvir is a nucleotide analog NS5B polymerase inhibitor, while Velpatasvir is an NS5A inhibitor. Together, they work synergistically to inhibit the replication of the HCV across genotypes 1–6.
Category | Antiviral Agent) |
Brand | Aprazer |
Ingredient | Sofosbuvir |
Prescription Required | Yes |
Strength | 400/100mg |
Package | 28 Tablets |
Velakast 400 mg, which combines Sofosbuvir (400 mg) and Velpatasvir (100 mg), works by targeting different stages of the Hepatitis C Virus (HCV) lifecycle to inhibit its replication. Sofosbuvir, a nucleotide analog, works by blocking the NS5B polymerase enzyme, which is essential for viral RNA replication, thereby preventing the virus from multiplying.
Velakast 400 mg, which combines Sofosbuvir and Velpatasvir, offers several significant benefits for individuals with chronic Hepatitis C Virus (HCV) infection. The combination of these two potent antiviral agents targets multiple stages of the HCV lifecycle, effectively inhibiting viral replication and leading to a reduction in the viral load.
The most common side effects of Velakast 400mg are:
Other side effects of Velakast 400mg can include:
Velakast 400 mg (Sofosbuvir and Velpatasvir) should not be taken by individuals who are allergic to any of its components, as an allergic reaction could lead to severe side effects. It is also contraindicated in people with severe liver disease, such as decompensated cirrhosis, as the medication may worsen liver function in such cases. Those with a history of severe kidney impairment, particularly those on dialysis, should avoid using Velakast, as it may not be safe for them due to the way the drug is processed in the body.
Velakast 400 mg should be taken exactly as prescribed by your healthcare provider. It is typically taken once daily, with or without food, at the same time each day to maintain a consistent level of the medication in your body. The tablet should be swallowed whole with water and not crushed, chewed, or split. The usual duration of treatment is 12 weeks, although this may vary depending on the severity of the infection, the HCV genotype, and whether the patient has liver damage such as cirrhosis
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