How Does Knilonat 150mg Work

Knilonat 150mg works by targeting and inhibiting a specific abnormal protein known as BCR-ABL tyrosine kinase, which is produced by a genetic mutation in patients with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). This abnormal protein sends continuous signals that cause white blood cells to grow and divide uncontrollably.

Benefits Of Knilonat 150mg

Knilonat 150mg offers several important benefits for patients diagnosed with Philadelphia chromosome-positive chronic myeloid leukemia (Ph+ CML). Its primary advantage lies in its ability to specifically target the abnormal BCR-ABL tyrosine kinase enzyme that drives the uncontrolled growth of leukemic cells. By blocking this enzyme, Knilonat effectively slows disease progression and reduces the number of cancerous white blood cells.

The most common side effects of Knilonat 150mg are
• Nausea
• Vomiting
• Diarrhea or constipation
• Headache
• Fatigue
• Rash or itching
• Abdominal pain
• Muscle or joint pain
• Hair loss (alopecia)
• Cough
• Fever
• Loss of appetite
• Increased liver enzymes (seen in blood tests)

Other side effects of Knilonat 150mg can include
• Heart problems (e.g., QT prolongation, irregular heartbeat)
• High blood pressure (hypertension)
• Pancreatitis (inflammation of the pancreas)
• Elevated blood sugar levels (hyperglycemia)
• Low blood counts,
• Liver toxicity (elevated liver enzymes, jaundice)
• Electrolyte imbalances (low potassium or magnesium)
• Fluid retention or swelling (edema)
• Shortness of breath
• Skin peeling or blistering
• Infections due to suppressed immunity

Who Should Not Take Knilonat 150mg

Knilonat 150mg should not be taken by individuals who have a known allergy or hypersensitivity to Nilotinib or any of the ingredients in the medication. It is also contraindicated in patients with certain heart conditions, such as long QT syndrome, as the drug can prolong the QT interval and increase the risk of serious and potentially life-threatening arrhythmias. People with severe liver impairment should avoid using Knilonat, as the drug is metabolized in the liver and may accumulate to harmful levels. Additionally, patients with uncontrolled hypokalemia or hypomagnesemia should correct these electrolyte imbalances before starting the medication.

How To Take Knilonat 150mg

Knilonat 150mg should be taken exactly as prescribed by a healthcare professional, usually twice daily, approximately 12 hours apart. It must be taken on an empty stomach, at least 2 hours before or 1 hour after eating, as food can significantly increase the absorption of the drug, raising the risk of side effects such as heart rhythm problems. The capsule should be swallowed whole with a glass of water and should not be crushed or chewed.